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Pregnenolone

Pregnenolone is a master steroid precursor synthesized from cholesterol, with preliminary evidence suggesting benefits for memory, neuroplasticity, depression, & fatigue through neurosteroid & GABA modulation.

cognitivehormonalmemorymood

Evidence last reviewed: 05 Apr 2026

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Evidence
3 records
3 recordsBest grade:Moderate
Biomarkers
CortisolDHEA / DHEA-SCognitive FunctionNeuroprotection / NGFMemory

The evidence for pregnenolone is mixed, with some studies showing potential benefits in cognitive function and neuroprotection, particularly in specific populations. However, the overall strength of the evidence is low to moderate, indicating a need for further research.

Cognitive function
Patients with schizophrenia · Systematic review
Moderate

Pregnenolone, as an add-on therapy, improved cognitive function in patients with schizophrenia.

Dose: 50 mg
Citation: Marx et al. (2011). Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence.
Hormonal balance
Patients with anorexia nervosa · Systematic review
Low

Pregnenolone levels were reviewed in the context of hormonal changes in anorexia nervosa.

Dose: 50 mg
Citation: Arteaga-Henríquez et al. (2023). Immunoregulatory and/or Anti-inflammatory Agents for the Management of Core and Associated Symptoms in Individuals with Autism Spectrum Disorder: A Narrative Review of Randomized, Placebo-Controlled Trials.
The study highlights the role of pregnenolone in hormonal regulation.
Neuroprotection
Patients with bipolar depression · RCT
Low

Pregnenolone was found to be neuroprotective & enhanced learning & memory.

Dose: 50 mg
Citation: Brown et al. (2014). A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression.
The study suggests potential benefits in enhancing learning & memory.
Stacks containing Pregnenolone
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hormonalmoodbalance

Hormonal Balance and Mood Enhancement

by@athlete

Combining Pregnenolone with SAMe can support hormonal balance and enhance mood. Pregnenolone is a precursor to various hormones, supporting hormonal balance, while SAMe is known for its mood-enhancing and joint-supporting properties.

Pregnenolone
50mg
SAMe (S-Adenosyl-L-Methionine)
400mg
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Forms & usage▾
How to take it

Typical doses range from 5 to 50 mg daily, taken in the morning.

Capsule
Commonly available in 10 mg to 100 mg dosages.
Tablet
Available in various dosages, often used for precise dosing.
Sublingual
Allows for faster absorption compared to oral forms.
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