Pregabalin
Pregabalin is a medication used to treat epilepsy, fibromyalgia, neuropathic pain, & generalized anxiety disorder. It is known for its anxiolytic effects & is more potent than gabapentin.
Evidence last reviewed: 05 Apr 2026
Not a routine supplement — not recommended for self-directed use.
Information here is educational only, not a recommendation to use. See our Safety page.
Evidence is from research or clinical settings — does not imply safety outside supervised contexts.
Pregabalin has strong evidence for reducing neuropathic pain and moderate evidence for anxiety management. However, it is not effective for sciatica pain, highlighting the need for careful patient selection.
AnxietyAdults with anxiety disorders · Systematic reviewModerate
Pregabalin shows potential benefits for anxiety management.
Neuropathic painAdults with neuropathic pain · Meta-analysisHigh
Pregabalin was found to be effective in reducing neuropathic pain.
Addiction riskGeneral population · Systematic reviewLow
Limited evidence of addiction risk associated with pregabalin.
Sciatica painAdults with sciatica · Systematic reviewModerate
Pregabalin was not effective for sciatica pain management.