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Pramiracetam

Pramiracetam is a potent nootropic that enhances high-affinity choline uptake, potentially improving long-term memory formation & attention, particularly in individuals with cognitive impairment.

cognitivememoryfocusneuroprotection

Evidence last reviewed: 05 Apr 2026

Evidence
2 records
2 recordsBest grade:Moderate
Biomarkers
Cognitive FunctionMemory

The evidence for Pramiracetam suggests it may enhance cognition and memory, particularly in individuals with cognitive impairment. However, the overall strength of the evidence is low, with limited clinical studies available. Most findings are based on pharmacological data rather than robust clinical trials.

Pharmacokinetics
Normal male volunteers · RCT
Moderate

Pramiracetam showed a peak plasma concentration between 2 to 3 hours post-administration with a half-life of 4.5 to 6.5 hours.

Dose: 400 mgTiming: After an overnight fast
Cognitive enhancement
Individuals with cognitive impairment · Systematic review
Low

Pramiracetam is suggested to enhance cognition & memory, though evidence is limited & primarily based on pharmacological properties.

Dose: 400 mg
The review discusses pramiracetam among other racetams, highlighting its potential but limited clinical evidence.
Stacks containing Pramiracetam
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cognitivemoodfocus

Pramiracetam & phenylalanine are combined to support cognitive function & mood. Pramiracetam enhances memory & cognitive performance, while phenylalanine supports mood & cognitive function by acting as a precursor to neurotransmitters.

Pramiracetam
400mg
L-Phenylalanine
500mg
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Forms & usage
How to take it

Take 400-600 mg daily, ideally in the morning or early afternoon.

Capsule
Commonly available in 400 mg capsules.
Powder
Can be mixed with liquids for flexible dosing.
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