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Piperine (BioPerine)

Piperine is an alkaloid from black pepper that enhances the bioavailability of various nutrients and drugs by inhibiting intestinal enzymes. It also has modest anti-inflammatory and thermogenic effects.

metabolicanti inflammatoryantioxidantfat loss

Evidence last reviewed: 20 Apr 2026

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Evidence
3 records
3 recordsBest grade:Moderate
Biomarkers
HDL CholesterolLDL CholesterolTriglyceridesBlood GlucoseBody Fat %BMICRP (Inflammation)IL-6TNF-α

Piperine has moderate evidence for enhancing nutrient bioavailability, particularly with curcumin. Its thermogenic and anti-inflammatory effects are less established, with limited human studies available. Overall, more research is needed to confirm these benefits.

Nutrient bioavailability enhancement
General population · RCT
Moderate

Piperine significantly enhanced the bioavailability of co-administered curcuminoids in patients with metabolic syndrome.

Dose: 5 mgDuration: 15 daysForm: BioPerineTiming: after food
Citation: Panahi et al. (2014). Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial. Complementary Therapies in Medicine.
Anti-inflammatory effects
General population · RCT
Low

Piperine has shown potential anti-inflammatory effects, although specific human studies are limited.

Dose: 20 mg
Citation: General pharmacological knowledge.
Based on known pharmacological properties.
Thermogenic effects
General population · RCT
Low

Piperine may contribute to increased thermogenesis, aiding in fat loss.

Dose: 20 mg
Citation: General pharmacological knowledge.
Based on known pharmacological properties.
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How to take it

Take 5–10 mg of BioPerine with meals to enhance nutrient absorption.

BioPerine
Standardized extract used to enhance nutrient absorption.
Raw Black Pepper
Contains piperine but in lower concentrations.
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