Research shows moderate evidence for phosphatidylserine's ability to lower cortisol after exercise and improve memory in older adults. However, more studies are needed to fully understand its effects across different populations.
Exercise-induced cortisol / cognitive stressHealthy adults; older adults · RCTsModerate
Attenuates post-exercise cortisol spike; some benefit to memory in cognitively declining adults.
Stress & Cognitive Support
Rhodiola rosea & phosphatidylserine are combined to support stress reduction & cognitive function. Rhodiola rosea is an adaptogen that enhances resilience to stress, while phosphatidylserine supports cognitive performance & reduces stress-related cortisol levels.
Forms & usage▾
Take 100–300 mg daily with food for best absorption.
Safety & trade-offs2▾
Significant cortisol attenuation — avoid if cortisol is already low or adrenal insufficiency is suspected
GI discomfort at high doses; fat-soluble — take with food
Context: doses >800mg
●High ●Moderate ● Low / note