Phosphatidylcholine
Phosphatidylcholine is a major phospholipid component of cell membranes and serves as a direct choline source for acetylcholine synthesis. It is used for liver protection and cognitive function preservation, and as a delivery vehicle for other lipophilic nutrients.
Evidence last reviewed: 20 Apr 2026
The evidence suggests that phosphatidylcholine may enhance cognitive function through increased choline availability, though this is based on low-quality studies. Stronger support exists for its role in improving remission rates in ulcerative colitis patients. Further research is needed to clarify its broader effects.
Choline metabolite levelsGeneral population · Mendelian randomizationModerate
Phosphatidylcholine was associated with increased choline metabolite levels, which may mediate effects on type 2 diabetes.
Cognitive functionGeneral population · Systematic reviewLow
Phosphatidylcholine supplementation is suggested to support cognitive function through choline availability.
Ulcerative colitis remissionPatients with ulcerative colitis · Meta-analysisHigh
Phosphatidylcholine improved remission rates and clinical outcomes significantly over placebo.
Forms & usage▾
Take 1,000 mg daily with meals for best absorption.