Evidence
1 record1 recordBest grade:Moderate
Biomarkers
Insulin SensitivityMuscle Endurance
Current evidence shows NMN reliably raises NAD+ levels and may improve insulin sensitivity and muscle endurance in older adults. However, the long-term effects and safety in humans remain unclear, and more research is needed.
NAD+ levels / metabolic markersOlder adults; insulin-resistant individuals · RCTs (phase I/II)Moderate
NAD+ levels / metabolic markers
Older adults; insulin-resistant individuals · RCTs (phase I/II)
Reliably raises blood NAD+; some improvements in insulin sensitivity & muscle endurance in older adults.
Dose: 500 mgDuration: 8–12 weeks
Human trial data growing; long-term effects unknown.
Stacks containing Nicotinamide Mononucleotide (NMN)
Explore all →No public stacks include this supplement yet.
Community Insights
Forms & usage▾
How to take it
Take 250-500 mg daily, preferably in the morning.
NMN powder / capsule
Sublingual may improve absorption.
Liposomal NMN
Claimed better bioavailability; limited comparative data.
Safety & trade-offs2▾
Note
May fuel pre-existing cancer cell growth in preclinical models (NAD+ supports cell proliferation) — human significance unclear
Note
FDA has raised exclusion concerns for NMN as a dietary supplement — regulatory status is legally ambiguous in the US
●High ●Moderate ● Low / note
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