Niacin (Vitamin B3)
Niacin is an essential B vitamin that supports energy metabolism and is used in pharmacological doses to improve lipid profiles by raising HDL cholesterol and lowering triglycerides and LDL cholesterol. It is also used as nicotinamide for skin health and NAD synthesis support.
Evidence last reviewed: 20 Apr 2026
The evidence supports niacin's role in improving lipid profiles and its potential benefits for NAD+ synthesis and skin health. While the strength of the studies is generally high, individual responses may vary, and more research is needed in some areas.
Lipid profile improvementPatients with coronary artery disease · Systematic reviewHigh
Niacin therapy was found to improve lipid profiles by raising HDL cholesterol and lowering triglycerides and LDL cholesterol.
NAD+ synthesis supportGeneral population · Systematic reviewModerate
Niacin is a precursor to NAD+, supporting cellular energy metabolism.
Glaucoma risk reductionIndividuals with high niacin consumption · Systematic review and Meta-analysisModerate
Higher niacin consumption was associated with a lower risk of glaucoma.
Skin cancer chemopreventionIndividuals at risk for non-melanoma skin cancers · Systematic review and Meta-analysisModerate
Nicotinamide was found to have a protective role against skin cancer recurrence.
Forms & usage▾
Take 500-2000 mg daily, preferably with meals.