Naltrexone
Naltrexone is an opioid receptor antagonist primarily used for treating alcohol & opioid use disorders. It is also being studied in low doses for autoimmune conditions & chronic pain disorders like fibromyalgia.
Evidence last reviewed: 05 Apr 2026
Not a routine supplement — not recommended for self-directed use.
Information here is educational only, not a recommendation to use. See our Safety page.
Evidence is from research or clinical settings — does not imply safety outside supervised contexts.
Naltrexone has strong evidence supporting its use in treating alcohol use disorder, with moderate evidence for impulse control disorders. However, studies on its effectiveness for binge-eating disorder are limited and primarily focus on alcohol consumption outcomes.
Impulse control disordersAdults with impulse control disorders · Systematic reviewModerate
Naltrexone was evaluated for impulse control disorders with moderate strength of evidence for benefit.
Alcohol use disorderAdults with alcohol use disorder · Systematic review and Meta-analysisHigh
Oral naltrexone at 50 mg/day is associated with lower rates of return to heavy drinking.
Alcohol use disorderAdults with alcohol use disorder · Systematic review and Meta-analysisHigh
Supports the use of oral naltrexone at 50 mg/day as a first-line pharmacotherapy for alcohol use disorder.
Binge-eating disorderAdults with binge-eating disorder · RCTLow
Naltrexone/bupropion was studied for binge-eating disorder, with primary outcomes focused on alcohol consumption.