MSM (Methylsulfonylmethane)
Studied for joint pain/function outcomes; evidence includes placebo-controlled trials with modest improvements in knee OA symptom scores.
Evidence last reviewed: 04 Apr 2026
- •allergic to sulfur compounds
- •pregnant or breastfeeding
- •under 18 years old
The evidence for MSM includes low-quality trials showing modest improvements in knee pain and function. While some studies report benefits, the overall strength of the evidence is limited, and more research is needed to confirm its effectiveness.
Knee osteoarthritis pain/functionAdults with knee OA · RCTLow
Double-blind placebo-controlled trial reported improvements in pain & physical function with MSM 3 g twice daily for 12 weeks.
Knee joint quality of life / mild knee painHealthy adults with mild knee pain (not clinical OA) · RCTLow
Double-blind RCT (n=88) found MSM 2,000 mg/day for 12 weeks significantly improved total JKOM knee symptom scores (p=0.046) & self-reported health condition (p=0.032) vs placebo in participants with mild knee pain.
Combining MSM with Serrapeptase can support joint health and reduce inflammation. MSM is known for its joint-supporting properties, while Serrapeptase provides anti-inflammatory and pain-relieving effects.
Joint Health & Recovery
Glucosamine & MSM are combined to support joint health & recovery. Glucosamine aids in cartilage repair & reduces joint pain, while MSM provides anti-inflammatory support & enhances joint flexibility.
Joint & Training Resilience (Low-Drama)
Simple add-ons for soreness/joint comfort signals during heavy training blocks.
Forms & usage▾
Take 2,000 to 3,000 mg daily, ideally in divided doses.