Manganese has moderate evidence supporting its role in bone health and antioxidant enzyme function. However, the evidence for cognitive performance is limited, indicating a need for further research. Overall, it is a beneficial mineral but should be taken with caution regarding dosage.
Antioxidant enzyme functionGeneral population · Systematic reviewModerate
Manganese is critical for the function of antioxidant enzymes such as MnSOD, which plays a role in protecting cells from oxidative damage.
Bone healthGeneral population · Systematic reviewModerate
Manganese supports bone formation and collagen synthesis, contributing to overall bone health.
Cognitive performanceAdults · Meta-analysisLow
Manganese exposure has been associated with cognitive performance, though further interventional studies are needed.
Antitumor immune responsesCancer patients · Systematic reviewLow
Manganese is critical for antitumor immune responses via the cGAS-STING pathway, potentially improving the efficacy of clinical immunotherapy.
Forms & usage▾
Take 1-2 mg daily with food for optimal absorption.