Lexapro (Escitalopram)
Lexapro is a highly selective SSRI used primarily for treating depression & generalized anxiety disorder, known for its favorable tolerability & efficacy.
Evidence last reviewed: 05 Apr 2026
Not a routine supplement — not recommended for self-directed use.
Information here is educational only, not a recommendation to use. See our Safety page.
Evidence is from research or clinical settings — does not imply safety outside supervised contexts.
The evidence supports Lexapro's efficacy in reducing symptoms of depression and anxiety, with high-quality studies confirming its effectiveness. However, gastrointestinal side effects are a noted concern, similar to other SSRIs.
Anxiety reductionAdults with anxiety disorders · RCTHigh
Escitalopram was found to be noninferior to mindfulness-based stress reduction in reducing anxiety symptoms.
Depression symptom reductionAdults with major depressive disorder · RCTHigh
Escitalopram showed significant reduction in depression symptoms, comparable to psilocybin.
Depression maintenance treatmentAdults with major depressive disorder · Systematic review and meta-analysisHigh
Escitalopram is effective in the maintenance phase of major depressive disorder.
Gastrointestinal side effectsPatients with major depressive disorder · Systematic review and meta-analysisModerate
Escitalopram is associated with gastrointestinal side effects, similar to other antidepressants.
Anxiety reduction in adolescentsAdolescents with generalized anxiety disorder · RCTHigh
Escitalopram significantly reduced anxiety symptoms in adolescents.