Lactobacillus crispatus

Lactobacillus crispatus is a probiotic that helps maintain a healthy vaginal microbiome, primarily used to prevent bacterial vaginosis and support vaginal health in women.

vaginal healthgut healthwomens healthimmune support

Evidence last reviewed: 20 Apr 2026

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Evidence

3 records

3 recordsBest grade:High

The evidence for Lactobacillus crispatus is moderate to high, particularly in preventing bacterial vaginosis recurrence and aiding in microbiome restoration. However, the overall research is limited, and more studies are needed to confirm its efficacy in broader contexts.

Recurrence of bacterial vaginosis

Women aged 18 to 45 with a history of bacterial vaginosis · RCT

High

Lactobacillus crispatus CTV-05 significantly reduced the recurrence of bacterial vaginosis compared to placebo.

Dose: —Duration: 11 weeksForm: Lactin-V

Citation: Cohen et al. (2020). Randomized Trial of Lactin-V to Prevent Recurrence of Bacterial Vaginosis. NEJM.

Vaginal microbiome restoration

Women aged 18 to 45 post-metronidazole treatment for bacterial vaginosis · RCT

Moderate

Lactobacillus crispatus CTV-05 was detected in 79% of participants, indicating successful colonization and microbiome restoration.

Dose: —Duration: 24 weeksForm: Lactin-V

Citation: Mändar et al. (2023). Impact of Lactobacillus crispatus-containing oral and vaginal probiotics on vaginal health. Clinical Trial.

Prevention of urinary tract infections

Women with a history of bacterial vaginosis · Systematic review

Low

Lactobacillus crispatus suppositories may help reduce the incidence of urinary tract infections.

Dose: —Form: Vaginal suppository

Citation: Shoureshi et al. (2023). Can vaginal lactobacillus suppositories help reduce urinary tract infections?. Nature Medicine.

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Forms & usage▾

How to take it

Take as directed, typically in capsule or suppository form, preferably at bedtime.

Vaginal suppository

Direct application to the vaginal area for targeted microbiome support.

Oral capsule

Systemic probiotic support, though less direct for vaginal health.

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