Lactobacillus crispatus
Lactobacillus crispatus is a probiotic that helps maintain a healthy vaginal microbiome, primarily used to prevent bacterial vaginosis and support vaginal health in women.
Evidence last reviewed: 20 Apr 2026
- •pregnant women without medical advice
- •those with severe allergies to probiotics
- •individuals with compromised immune systems
The evidence for Lactobacillus crispatus is moderate to high, particularly in preventing bacterial vaginosis recurrence and aiding in microbiome restoration. However, the overall research is limited, and more studies are needed to confirm its efficacy in broader contexts.
Recurrence of bacterial vaginosisWomen aged 18 to 45 with a history of bacterial vaginosis · RCTHigh
Lactobacillus crispatus CTV-05 significantly reduced the recurrence of bacterial vaginosis compared to placebo.
Vaginal microbiome restorationWomen aged 18 to 45 post-metronidazole treatment for bacterial vaginosis · RCTModerate
Lactobacillus crispatus CTV-05 was detected in 79% of participants, indicating successful colonization and microbiome restoration.
Prevention of urinary tract infectionsWomen with a history of bacterial vaginosis · Systematic reviewLow
Lactobacillus crispatus suppositories may help reduce the incidence of urinary tract infections.
Forms & usage▾
Take as directed, typically in capsule or suppository form, preferably at bedtime.