Lactobacillus acidophilus
Lactobacillus acidophilus is a probiotic strain that supports gut and vaginal health, with evidence for reducing IBS symptoms, preventing UTIs, and modulating cholesterol levels.
Evidence last reviewed: 20 Apr 2026
The evidence for Lactobacillus acidophilus includes moderate support for gut health and vaginal flora maintenance, with some low-quality studies suggesting benefits for liver health and cognitive function. However, more high-quality research is needed to fully establish its efficacy across all proposed benefits.
Gut microbiota modulationChildren with antibiotic-associated diarrhea · RCTModerate
Lactobacillus acidophilus reduced the overall risk of diarrhea during and after antibiotic treatment.
Cognitive function recoveryPatients with cerebral ischemia · RCTLow
Lactobacillus acidophilus promoted cognitive function recovery by regulating microglial peroxisomal function.
Cholestatic liver injury ameliorationPatients with cholestatic liver injury · RCTLow
Lactobacillus acidophilus ameliorated liver injury by inhibiting bile acid synthesis and promoting excretion.
Vaginal flora maintenanceWomen with recurrent vulvovaginal candidiasis · RCTModerate
Probiotics, including Lactobacillus acidophilus, were effective as maintenance treatment for recurrent vulvovaginal candidiasis.
Forms & usage▾
Take 1–2 capsules daily with water, preferably on an empty stomach.