L-Lysine
L-Lysine is an essential amino acid that plays a crucial role in protein synthesis and various metabolic processes. It is commonly used as a dietary supplement to support immune function, promote collagen formation, and potentially reduce anxiety.
Evidence last reviewed: 29 Apr 2026
The evidence for L-Lysine is moderate to high, particularly for immune enhancement and herpes simplex virus management. While it shows potential for anxiety reduction and muscle recovery, more research is needed to fully understand its effects.
Anxiety reductionAdults with mild anxiety · Randomized Controlled TrialModerate
Significant reduction in anxiety symptoms compared to placebo.
Immune function enhancementHealthy adults · Clinical TrialHigh
Improved immune markers and reduced incidence of common colds.
Improved collagen synthesisAdults with skin aging concerns · Open Label StudyModerate
Enhanced collagen production and improved skin elasticity.
Reduction in herpes simplex virus outbreaksAdults with recurrent herpes simplex virus · Randomized Controlled TrialHigh
Reduced frequency and severity of herpes outbreaks.
Improved muscle recoveryAthletes · Clinical TrialModerate
Faster recovery and reduced muscle soreness post-exercise.
Longevity Mix (Bryan Johnson)
Bryan Johnson's Blueprint Longevity Mix is the core daily powder from his self-quantified anti-aging protocol. It combines NAD+ pathway support (CaAKG), collagen precursors (Glycine, Lysine, Vitamin C), joint protection (Glucosamine, Sodium Hyaluronate), mitochondrial support (Creatine, CoQ10-adjacent), and antioxidant defence (Glutathione, Taurine). Every ingredient is dosed at clinically relevant levels validated through continuous biomarker tracking.
Forms & usage▾
Take 500-1000 mg daily, preferably with meals.
Safety & trade-offs1▾
Potential gastrointestinal discomfort
Context: High doses may cause stomach upset or diarrhea.
●High ●Moderate ● Low / note