Kanna (Sceletium tortuosum)
Kanna is a South African succulent known for its mood-enhancing and anxiolytic effects, primarily due to its mesembrine alkaloids that act as selective serotonin reuptake inhibitors and PDE4 inhibitors.
Evidence last reviewed: 20 Apr 2026
Kanna has moderate evidence for improving mood and reducing anxiety in adults with mild anxiety. However, the evidence for cognitive function and cortisol reduction is limited and requires further investigation.
Mood enhancementAdults with mild anxiety · RCTModerate
Kanna extract significantly improved mood and reduced anxiety symptoms.
Cognitive functionHealthy adults · RCTLow
Acute administration of Kanna improved executive function and cognitive flexibility.
Cortisol reductionAdults under stress · RCTLow
Kanna supplementation led to a significant reduction in cortisol levels.
Mood and Anxiety Support
Combining Kanna and Saffron can provide mood enhancement and anxiety reduction. Kanna is known for its anxiolytic and mood-enhancing properties, while Saffron has been shown to improve mood and reduce symptoms of anxiety.
Forms & usage▾
Take 100-200 mg of Kanna extract daily, preferably in the morning.