Hesperidin
Hesperidin is a flavanone glycoside from citrus peel that improves microvascular circulation, reduces symptoms of venous insufficiency, and has anti-inflammatory and antioxidant properties. It is often paired with diosmin for maximum vascular effect and is used to reduce leg swelling, hemorrhoids, and improve endothelial function in metabolic syndrome.
Evidence last reviewed: 20 Apr 2026
The evidence suggests moderate benefits for improving microvascular circulation and venous tone, particularly in those with chronic venous insufficiency. However, the overall quality of studies is low to moderate, indicating a need for more rigorous research.
Microvascular circulation improvementAdults with chronic venous insufficiency · Systematic reviewModerate
Hesperidin, often in combination with diosmin, improves symptoms of chronic venous insufficiency, such as leg swelling and pain.
Oxidative stress reductionAdults with chronic venous disease · Systematic reviewLow
Hesperidin may help reduce oxidative stress in individuals with chronic venous disease.
Venous tone improvementAdults with chronic venous insufficiency · Systematic reviewModerate
Hesperidin, as part of venoactive compounds, improves venous tone and reduces symptoms of venous insufficiency.
Inflammatory marker reductionAdults with inflammatory conditions · Systematic review and meta-analysisLow
Hesperidin supplementation may reduce inflammatory markers, although more RCTs are needed to confirm these effects.
Forms & usage▾
Take 500-1000 mg daily, preferably with food.