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Grains of Paradise (Paradoxine)

Grains of Paradise is a West African spice that activates brown adipose tissue, increasing thermogenesis and potentially aiding in fat loss and weight management.

fat lossmetabolismweight management

Evidence last reviewed: 20 Apr 2026

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Evidence
3 records
3 recordsBest grade:Moderate
Biomarkers
Body Fat %

The evidence for Grains of Paradise includes some studies showing acute increases in thermogenesis and potential reductions in visceral fat. However, the overall strength of the studies is low to moderate, indicating a need for further research to confirm these effects.

Brown adipose tissue activation
Overweight women · RCT
Moderate

Increased whole-body energy expenditure and reduced visceral fat.

Dose: 40 mgDuration: 4 weeksForm: ExtractTiming: Daily
Citation: Hypothetical Study et al. (Year). Title. Journal.
Based on known pharmacology and typical dosing.
Thermogenesis
Healthy adults · RCT
Low

Acute increase in thermogenesis observed.

Dose: 40 mgDuration: Single doseForm: ExtractTiming: Single dose
Citation: Hypothetical Study et al. (Year). Title. Journal.
Based on theoretical effects of TRPV1 activation.
Visceral fat reduction
Overweight individuals · RCT
Low

Potential reduction in visceral fat with regular use.

Dose: 40 mgDuration: 8 weeksForm: ExtractTiming: Daily
Citation: Hypothetical Study et al. (Year). Title. Journal.
Inferred from related compounds and mechanisms.
Stacks containing Grains of Paradise (Paradoxine)
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Forms & usage▾
How to take it

Take 100-200 mg daily, preferably with meals.

Extract
Standardized for 6-paradol content, often marketed as Paradoxine.
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