Research indicates that liposomal and S-acetyl glutathione can significantly increase blood levels of glutathione and improve oxidative stress markers. However, studies are limited in size and scope, necessitating further investigation into long-term effects and optimal dosing.
Oxidative stress markers / immune functionHealthy adults; older adults · RCTs (small)Moderate
Liposomal & S-acetyl forms show meaningful increases in blood GSH; oxidative stress markers improve.
Longevity Mix (Bryan Johnson)
Bryan Johnson's Blueprint Longevity Mix is the core daily powder from his self-quantified anti-aging protocol. It combines NAD+ pathway support (CaAKG), collagen precursors (Glycine, Lysine, Vitamin C), joint protection (Glucosamine, Sodium Hyaluronate), mitochondrial support (Creatine, CoQ10-adjacent), and antioxidant defence (Glutathione, Taurine). Every ingredient is dosed at clinically relevant levels validated through continuous biomarker tracking.
Forms & usage▾
Take 250-500 mg of liposomal or S-acetyl glutathione daily, ideally on an empty stomach.
Safety & trade-offs2▾
Standard oral reduced glutathione has poor bioavailability — liposomal or S-acetyl form required for meaningful absorption
High-dose antioxidant supplementation may blunt exercise-induced ROS signalling, potentially reducing training adaptations
Context: doses >500mg/day during high-volume training
●High ●Moderate ● Low / note