GHRP-6

GHRP-6 is a synthetic hexapeptide ghrelin receptor agonist that produces a substantial GH pulse alongside a pronounced increase in appetite and hunger — properties that mirror endogenous ghrelin, whose primary physiological role is appetite regulation at the hypothalamic level. The appetite stimulation makes it potentially useful in contexts such as cachexia or conditions requiring increased caloric intake, but difficult to manage for individuals pursuing body recomposition. Like GHRP-2, it causes moderate cortisol and prolactin elevation with the pulse, though generally to a lesser degree than GHRP-2. Clinical research is more extensive than for many newer peptides, spanning GH deficiency and critical illness literature, but no regulatory approval exists for performance or wellness applications.

Evidence last reviewed: 19 Apr 2026