GHRP-2
GHRP-2 is a synthetic hexapeptide ghrelin receptor agonist that produces a potent and reliable GH pulse, and has been used in research settings as a diagnostic provocative test for GH secretory capacity. Beyond GH release, GHRP-2 meaningfully elevates cortisol, prolactin, and ACTH — particularly at higher doses — a broader neuroendocrine activation profile that limits its appeal relative to more selective GHRPs like ipamorelin. Human pharmacokinetic and pharmacodynamic data are among the most well-characterized of any research GHRP, with studies in GH deficiency, cachexia, and critical illness contexts. Wellness use requires awareness of the cortisol and prolactin co-stimulation, and no regulatory approval exists outside of diagnostic and investigational research applications.
Evidence last reviewed: 19 Apr 2026
Not a routine supplement — not recommended for self-directed use.
Information here is educational only, not a recommendation to use. See our Safety page.
Verify this peptide on CertiPep
certipep.ch — anonymous purity & characterization service
Evidence is from research or clinical settings — does not imply safety outside supervised contexts.
GHRP-2 has moderate evidence supporting its effectiveness in stimulating GH secretion across various populations, including children and adults with GH deficiencies. However, its impact on cortisol and prolactin may limit its appeal for broader use.
GH secretionNormal adults · RCTModerate
GHRP-2 significantly increased GH levels compared to GHRH alone.
GH secretionChildren with GH insufficiency and idiopathic short stature · RCTModerate
GHRP-2 increased GH secretion in children with GH insufficiency and idiopathic short stature.
Cortisol secretionHealthy non-obese male volunteers · RCTModerate
GHRP-2 stimulated cortisol secretion, influenced by secretagogue type and sex-steroid milieu.
GH secretionYoung men with experimentally induced hypogonadism · RCTModerate
GHRP-2 maintained efficacy in stimulating GH release despite hypogonadism.
GH secretionChildren with GH insufficiency and idiopathic short stature · RCTModerate
GHRP-2 significantly increased GH levels compared to GHRH alone.