Fisetin
Fisetin is a flavonoid with senolytic properties that helps clear senescent cells, potentially aiding in longevity & reducing age-related biomarkers in the elderly.
Evidence last reviewed: 05 Apr 2026
- •pregnant or breastfeeding individuals
- •those with known allergies to flavonoids
- •people on blood thinners without doctor approval
The evidence for fisetin's benefits is primarily low quality, with systematic reviews suggesting potential senolytic, antioxidant, and neuroprotective effects. However, more robust studies are needed to confirm these findings and establish effective dosing.
Senolytic activityOlder individuals · Systematic reviewLow
Senotherapy, including fisetin, may eliminate senescent cells & reduce aging-associated disability & diseases.
Cancer preventionIndividuals at risk of cancer · Systematic reviewLow
Fisetin, as part of senotherapy, may decrease cancer incidence & improve treatment tolerance.
NeuroprotectionIndividuals with neurological diseases · Systematic reviewLow
Fisetin may offer neuroprotective benefits through its antioxidant & anti-inflammatory properties.
Antioxidant activityGeneral population · Systematic reviewLow
Fisetin reduces reactive oxygen species & upregulates antioxidant enzymes, potentially attenuating oxidative stress.
Metabolic & Antioxidant Support
Alpha-lipoic acid & fisetin are combined to support metabolic health & provide antioxidant benefits. Alpha-lipoic acid improves insulin sensitivity & supports metabolic function, while fisetin offers anti-aging & antioxidant support.
Forms & usage▾
Take 100-500 mg daily, preferably with food.