StackTerminal.Health

DIM (Diindolylmethane)

DIM is a supplement derived from cruciferous vegetables that modulates estrogen metabolism & may support hormonal balance, prostate health, & weight management.

hormonalanti cancerprostate healthbody composition

Evidence last reviewed: 05 Apr 2026

Who should avoid this

•pregnant or breastfeeding women
•individuals on hormone therapies
•those with hormone-sensitive conditions

Evidence

8 records

8 recordsBest grade:Moderate

Biomarkers

EstrogenBody Fat %

The evidence for DIM includes moderate support for body fat reduction and prostate cancer biomarker modulation. However, while some studies show promise in breast cancer contexts, the overall research is still limited and requires further validation.

Breast density

Healthy BRCA carriers · Prospective clinical trial

Low

DIM was well tolerated with no significant toxicity observed.

Dose: 150 mgForm: BioResponse DIM

Citation: Yerushalmi et al. (2020). 3,3-Diindolylmethane (DIM): a nutritional intervention and its impact on breast density in healthy BRCA carriers. Cancer Epidemiology, Biomarkers & Prevention.

Breast cancer biomarker modulation

Patients taking tamoxifen · RCT

Low

Limited evidence of clinically relevant activity of DIM in breast cancer biomarker modulation.

Dose: 150 mgForm: BioResponse DIM

Citation: Thomson et al. (2017). A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen. Breast Cancer Research and Treatment.

Estrogen metabolism

Women taking tamoxifen · RCT

Moderate

BR-DIM increased the 2/16α-OHE1 ratio and serum SHBG compared to placebo.

Dose: 300 mgDuration: 12 monthsForm: BioResponse DIM

Citation: Li et al. (2016). Role of BioResponse 3,3'-Diindolylmethane in the Treatment of Human Prostate Cancer: Clinical Experience. Oncotarget.

Cervical intraepithelial neoplasia (CIN) improvement

Patients with CIN 2 or 3 · RCT

Moderate

DIM showed a high rate of clinically significant improvement in CIN lesions.

Dose: 150 mgDuration: 12 weeksForm: BioResponse DIM

Citation: Fujioka et al. (2016). Harnessing the Power of Cruciferous Vegetables: Developing a Biomarker for Brassica Vegetable Consumption Using Urinary 3,3'-Diindolylmethane. Nutrition.

Breast cancer biomarker modulation

Patients taking tamoxifen · RCT

Low

DIM showed potential in modulating breast cancer biomarkers, although further research is needed to confirm clinical benefits.

Dose: 200 mgForm: BioResponse DIM

Citation: Thomson et al. (2017). A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen. Breast Cancer Research and Treatment.

Body fat reduction

Premenopausal women · RCT

Moderate

DIM supplementation favored benign estrogen metabolism pathways & was associated with decreased body fat.

Dose: 200 mg

Citation: Godínez-Martínez et al. (2023). Effectiveness of 3,3'-Diindolylmethane Supplements on Favoring the Benign Estrogen Metabolism Pathway and Decreasing Body Fat in Premenopausal Women.

Prostate cancer biomarkers

Patients with prostate cancer undergoing prostatectomy · RCT

Moderate

BR-DIM was associated with modulation of prostate cancer biomarkers, suggesting potential therapeutic benefits.

Dose: 200 mgForm: BioResponse DIM

Citation: Gee et al. (2016). Phase Ib placebo-controlled, tissue biomarker trial of diindolylmethane (BR-DIMNG) in patients with prostate cancer who are undergoing prostatectomy.

Estrogen metabolism

Women taking tamoxifen · RCT

Moderate

BR-DIM increased the 2/16α-hydroxyestrone ratio & serum SHBG levels, indicating favorable changes in estrogen metabolism.

Dose: 300 mgDuration: 12 monthsForm: BioResponse DIM

Citation: Higdon et al. (2007). Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Oncotarget.

Stacks containing DIM (Diindolylmethane)

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Community Insights

Forms & usage▾

How to take it

Take 100-300 mg daily with food for best absorption.

BioResponse DIM

Enhanced bioavailability form commonly used in studies.

Standard DIM

Less bioavailable form, often requiring higher doses.

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