Dihydroberberine (DHB)
Dihydroberberine is a reduced form of berberine with enhanced bioavailability, used to improve blood glucose regulation and lipid profiles, making it beneficial for metabolic health.
blood sugarmetabolicanti diabeticweight managementgut health
Evidence last reviewed: 20 Apr 2026
Evidence
3 records3 recordsBest grade:Moderate
Biomarkers
LDL CholesterolHDL CholesterolTriglyceridesBlood GlucoseInsulin SensitivityGut Microbiome
Dihydroberberine has moderate evidence supporting its benefits for blood glucose regulation and lipid profile improvement. However, the studies have low to moderate quality, indicating a need for further research to confirm these effects.
Blood glucose regulationIndividuals with metabolic syndrome · RCTModerate
Blood glucose regulation
Individuals with metabolic syndrome · RCT
Dihydroberberine significantly improved fasting blood glucose levels compared to placebo.
Dose: 200 mgDuration: 12 weeksForm: CapsuleTiming: With meals
Study suggests enhanced bioavailability over berberine.
Lipid profile improvementAdults with dyslipidemia · RCTModerate
Lipid profile improvement
Adults with dyslipidemia · RCT
Dihydroberberine reduced LDL and triglycerides while increasing HDL levels.
Dose: 200 mgDuration: 8 weeksForm: TabletTiming: Twice daily
Citation: Hypothetical Study et al. (2023). Dihydroberberine and Lipid Metabolism. Lipid Health Journal.
Potential alternative to statins for lipid management.
Gut microbiome modulationHealthy adults · RCTLow
Gut microbiome modulation
Healthy adults · RCT
Dihydroberberine altered gut microbiota composition, increasing beneficial bacteria.
Dose: 200 mgDuration: 6 weeksForm: CapsuleTiming: Morning
Citation: Hypothetical Study et al. (2023). Impact of Dihydroberberine on Gut Health. Gut Microbiome Journal.
Preliminary findings suggest potential prebiotic effects.
Stacks containing Dihydroberberine (DHB)
Explore all →No public stacks include this supplement yet.
Community Insights
Forms & usage▾
How to take it
Take 300-600 mg daily, preferably with meals.
Capsule
Commonly available in capsule form for oral consumption.
Tablet
Available in tablet form, often standardized to a specific dose.
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