D-Ribose
D-Ribose is a pentose sugar that plays a crucial role in ATP & nucleotide synthesis, showing potential benefits for individuals with chronic fatigue syndrome, fibromyalgia, cardiac energy depletion, & those needing exercise recovery.
Evidence last reviewed: 05 Apr 2026
The evidence for D-Ribose is varied, with some studies indicating benefits for heart function and fatigue, but overall quality is low to moderate. More robust research is needed to confirm its efficacy across broader populations.
mental fatiguehealthy adults · RCTLow
D-Ribose, in combination with caffeine, was studied for its effects on mental fatigue.
anaerobic capacityhealthy males · RCTLow
D-Ribose supplementation was evaluated for its effects on anaerobic capacity & metabolic markers.
quality of lifecongestive heart failure patients · Case seriesLow
D-Ribose improved diastolic function & quality of life in congestive heart failure patients.
cardiac performancepatients with heart failure with preserved ejection fraction · RCTModerate
D-Ribose supplementation showed potential to reduce symptoms & improve cardiac performance.
Forms & usage▾
Take 5 grams of D-Ribose powder 1-3 times daily, ideally before or after exercise.