Celexa (Citalopram)
Celexa is an SSRI approved for the treatment of major depressive disorder, with evidence showing good tolerability & effectiveness comparable to other SSRIs. However, higher doses may lead to QT prolongation.
Evidence last reviewed: 05 Apr 2026
Not a routine supplement — not recommended for self-directed use.
Information here is educational only, not a recommendation to use. See our Safety page.
Evidence is from research or clinical settings — does not imply safety outside supervised contexts.
Celexa has moderate to high evidence supporting its efficacy in treating major depressive disorder and related conditions. While it shows effectiveness comparable to other SSRIs, the potential for QT prolongation at higher doses is a notable concern.
Anxiety disordersAdults with anxiety disorders · Randomized Clinical TrialModerate
Escitalopram was noninferior to mindfulness-based stress reduction in reducing anxiety symptoms.
Post-stroke depressionAdults with post-stroke depression · Randomized controlled trialModerate
Escitalopram showed efficacy in reducing depressive symptoms in post-stroke patients.
Major depressive disorderAdults with major depressive disorder · Systematic review and meta-analysisHigh
Escitalopram was found to be effective in reducing depressive symptoms compared to placebo.
Depressive symptomsAdults with moderate-to-severe major depressive disorder · Randomized controlled trialModerate
Escitalopram was effective in reducing depressive symptoms, though less so than psilocybin.