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Cat's Claw (Uncaria tomentosa)

Cat's Claw is an Amazonian vine known for its anti-inflammatory and immune-modulating properties, potentially benefiting individuals with osteoarthritis and rheumatoid arthritis.

anti inflammatoryimmunejoint healthantioxidant

Evidence last reviewed: 20 Apr 2026

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Evidence
3 records
3 recordsBest grade:Moderate
Biomarkers
Immune Function

The evidence for Cat's Claw is mixed, with some studies indicating potential benefits for osteoarthritis and rheumatoid arthritis. However, the overall quality of research is low, and more rigorous studies are necessary to confirm its efficacy.

Rheumatoid arthritis symptom reduction
Patients with rheumatoid arthritis · RCT
Moderate

Cat's Claw extract showed a reduction in the number of painful joints compared to placebo.

Dose: 300 mgDuration: 24 weeksForm: Pentacyclic alkaloid-chemotype extract
Citation: Mur et al. (2002). Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of uncaria tomentosa for the treatment of rheumatoid arthritis. BMJ.
Osteoarthritis symptom improvement
Patients with osteoarthritis · Systematic review
Low

Cat's Claw may improve symptoms of osteoarthritis, though more high-quality research is needed.

Dose: 300 mg
Citation: Rosenbaum et al. (2010). Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. Systematic review.
Immune modulation
General population · Review
Very low

Cat's Claw has potential as an immunomodulating adaptogen, though specific human studies are lacking.

Dose: 300 mg
Citation: Della Valle et al. (2017). Uncaria tomentosa. Review.
Stacks containing Cat's Claw (Uncaria tomentosa)
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joint-healthanti-inflammatorypain

Joint Health and Anti-inflammatory Support

by@athlete

Combining Hyaluronic Acid with Cat's Claw can support joint health and reduce inflammation. Hyaluronic Acid is known for its joint-lubricating properties, while Cat's Claw provides anti-inflammatory and immune support.

Hyaluronic Acid
80mg
Cat's Claw (Uncaria tomentosa)
300mg
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Forms & usage▾
How to take it

Take 500 mg of Cat's Claw extract daily, preferably with meals.

Capsule
Commonly used for standardized dosing.
Powder
Can be mixed with liquids or foods.
Tincture
Liquid extract form for easy absorption.
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