Capsaicin
Capsaicin is an active compound in chili peppers known for activating TRPV1 receptors, which can increase thermogenesis and reduce appetite, potentially aiding in weight management and fat loss.
Evidence last reviewed: 20 Apr 2026
- •sensitive to spicy foods
- •gastrointestinal issues
- •pregnant or breastfeeding women
Moderate evidence supports capsaicin's role in increasing energy expenditure and reducing appetite, particularly in adults with overweight or obesity. However, individual responses may vary, and more research is needed to fully understand its long-term effects.
ThermogenesisAdults seeking weight management · Meta-analysisModerate
Capsaicin supplementation increased energy expenditure by approximately 50 kcal/day.
Appetite suppressionAdults with overweight or obesity · Systematic reviewModerate
Regular capsaicin intake was associated with reduced appetite and modest reductions in waist circumference.
Pain reliefAdults with neuropathic pain · Systematic reviewModerate
High-concentration capsaicin patches were effective for pain relief in neuropathic pain conditions.
Forms & usage▾
Take 2-6 mg of capsaicin daily, preferably with meals.