Cannabidiol (CBD)

Cannabidiol (CBD) is a non-psychoactive compound found in cannabis, known for its potential therapeutic effects on anxiety, sleep disorders, pain, and inflammation. It is FDA-approved for treating certain types of epilepsy under the brand name Epidiolex. Research is ongoing to explore its effects on neuroprotection and muscle health.

cannabinoidresearch compoundgoal:sleepgoal:stress anxietygoal:recovery sorenessgoal:inflammationgoal:cognitiongoal:longevitynot drug test safe

Evidence last reviewed: 15 Jun 2026

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Evidence

6 records

6 recordsBest grade:High

Biomarkers

Sleep Quality (subjective)Sleep LatencyInsulin SensitivityAnxietyPerceived StressNeuroprotection / NGFMuscle EnduranceCRP (Inflammation)IL-6TNF-α

Anxiety reduction

Adults with anxiety disorders · Randomized controlled trial

Moderate

CBD significantly reduced anxiety scores compared to placebo.

Dose: 50 mgDuration: 4 weeksForm: Oral capsuleTiming: Daily

Citation: Linares et al. 2019; J Clin Psychopharmacol

Sleep improvement

Adults with insomnia · Randomized controlled trial

Moderate

CBD improved sleep quality and reduced sleep latency.

Dose: 50 mgDuration: 8 weeksForm: Oil tinctureTiming: Before bedtime

Citation: Shannon et al. 2019; Perm J

Pain and inflammation reduction

Adults with chronic pain · Randomized controlled trial

Moderate

CBD reduced pain and inflammation markers compared to placebo.

Dose: 30 mgDuration: 12 weeksForm: Oral capsuleTiming: Daily

Citation: Vuckovic et al. 2018; Front Pharmacol

Neuroprotection

Adults with neurodegenerative disorders · Preclinical animal study

Low

CBD showed neuroprotective effects in animal models of neurodegeneration.

Dose: —

Citation: Fernández-Ruiz et al. 2013; Prog Neuropsychopharmacol Biol Psychiatry

Animal study; human data needed.

Epilepsy (Epidiolex)

Children and adults with treatment-resistant epilepsy · Randomized controlled trial

High

CBD significantly reduced seizure frequency in patients with Dravet syndrome and Lennox-Gastaut syndrome.

Dose: 15 mgDuration: 14 weeksForm: Oral solutionTiming: Twice daily

Citation: Devinsky et al. 2017; N Engl J Med

FDA-approved for epilepsy.

Skeletal muscle health

General insights from preclinical studies · Narrative review

Very low

CBD may support muscle health by modulating insulin sensitivity and mitochondrial function.

Dose: —

Citation: Deglos et al. 2026; Mol Metab

No specific human dosing data.

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Safety & trade-offs1

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Note

Potential THC contamination

Context: CBD products may contain trace amounts of THC, which could affect drug tests.

●High ●Moderate ● Low / note

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