Calcium Alpha-Ketoglutarate (CaAKG)
Calcium Alpha-Ketoglutarate (CaAKG) is a supplement studied for its potential geroprotective properties, aiming to reduce biological age and improve healthspan. It is being investigated for its effects on DNA methylation age, inflammatory markers, and metabolic parameters in middle-aged adults.
Evidence last reviewed: 29 Apr 2026
The evidence for CaAKG includes some promising findings on reducing DNA methylation age and improving inflammatory markers, but the overall strength of the studies is low to moderate. More robust research is needed to confirm these effects and establish optimal dosing.
Reduction in DNA methylation ageMiddle-aged adults with higher DNA methylation age · Randomized Controlled TrialModerate
Potential reduction in biological age as measured by DNA methylation.
Improvement in inflammatory markersMiddle-aged adults with higher DNA methylation age · Randomized Controlled TrialLow
Potential improvement in inflammatory markers.
Improvement in metabolic parametersMiddle-aged adults with higher DNA methylation age · Randomized Controlled TrialLow
Potential improvement in metabolic health.
Improvement in muscle strengthMiddle-aged adults with higher DNA methylation age · Randomized Controlled TrialLow
Potential improvement in handgrip and leg extension strength.
Longevity Mix (Bryan Johnson)
Bryan Johnson's Blueprint Longevity Mix is the core daily powder from his self-quantified anti-aging protocol. It combines NAD+ pathway support (CaAKG), collagen precursors (Glycine, Lysine, Vitamin C), joint protection (Glucosamine, Sodium Hyaluronate), mitochondrial support (Creatine, CoQ10-adjacent), and antioxidant defence (Glutathione, Taurine). Every ingredient is dosed at clinically relevant levels validated through continuous biomarker tracking.
Forms & usage▾
Take 1-2 grams daily, ideally with meals.
Safety & trade-offs1▾
Potential reduction in biological age
Context: May reduce DNA methylation age in biologically older individuals.
●High ●Moderate ● Low / note