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Agmatine Sulfate

Agmatine sulfate is an endogenous metabolite of arginine that may help reduce neuropathic pain and enhance mood. It is potentially beneficial for individuals with neuropathic conditions and those seeking cognitive benefits.

neuroprotectionpainmoodnootropiccognitive

Evidence last reviewed: 20 Apr 2026

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Evidence
2 records
2 recordsBest grade:Moderate
Biomarkers
Neuroprotection / NGF

The evidence for agmatine sulfate includes a case series showing pain reduction in neuropathic conditions and a moderate-quality RCT indicating neuroprotective effects. However, more robust studies are needed to confirm these findings.

Neuropathic pain reduction
Participants with painful small fiber neuropathy · Case series
Low

Agmatine sulfate was found to be effective in reducing neuropathic pain in participants with painful small fiber neuropathy.

Dose: 2670 mgDuration: 2 monthsForm: AgmaSet® capsules
Citation: Rosenberg et al. (2020). Evidence for Dietary Agmatine Sulfate Effectiveness in Neuropathies Associated with Painful Small Fiber Neuropathy. Nutrients.
Neuroprotection
Participants with herniated lumbar disc-associated radiculopathy · RCT
Moderate

Agmatine sulfate showed potential neuroprotective effects in participants with lumbar disc-associated radiculopathy.

Dose: 1000 mgDuration: 10 days
Citation: Keynan et al. (2010). Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc-associated Radiculopathy. MMWR.
Initial open-label dose escalation study followed by a double-blind trial.
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How to take it

Take 500-1000 mg daily, ideally on an empty stomach.

Capsule
Commonly available as AgmaSet® capsules containing G-Agmatine® brand of agmatine sulfate.
Powder
Can be mixed with liquids for easier consumption.
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