StackTerminal.Health

BETA
Research compound

This compound is primarily studied in research/clinical settings & may not be widely available as a regulated over-the-counter supplement. Information is provided for educational purposes only — not as a recommendation to use. See our Safety page.

Zoloft (Sertraline)

Zoloft is a widely prescribed SSRI used to treat depression, PTSD, OCD, panic disorder, & social anxiety, making it a first-line treatment for many anxiety & depressive disorders.

mental-healthdepressionanxietyptsd
Evidence last reviewed: 05 Apr 2026
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Evidence
5 records
Depression relapse prevention
Adults with major depressive disorderSystematic review
PUBMEDHigh

Sertraline was effective in preventing relapse in the maintenance phase of major depressive disorder.

Dose: 100 mgDuration: 6 months
PTSD symptom improvement
Adults with PTSDRCT
PUBMEDModerate

Sertraline, in combination with brexpiprazole, significantly improved PTSD symptoms compared to sertraline alone.

Dose: 150 mgDuration: 11 weeks
OCD symptom reduction
Children and adolescents with OCDRCT
PUBMEDModerate

Sertraline, alone or in combination with cognitive-behavioral therapy, was effective in reducing OCD symptoms.

Dose: 100 mgDuration: 10 weeks
Panic disorder treatment
Adults with panic disorder with or without agoraphobiaSystematic review
PUBMEDHigh

Sertraline was found to be effective in treating panic disorder, with a favorable safety profile.

Dose: 100 mg
Depression treatment in adolescents
Adolescents with depressionSystematic review
PUBMEDHigh

Sertraline was effective in treating depression in adolescents, with a good tolerability profile.

Dose: 100 mg
Forms
Tablet
Commonly prescribed form for oral administration.
Oral solution
Alternative for those who have difficulty swallowing tablets.

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