StackTerminal.Health

BETA
Research compound

This compound is primarily studied in research/clinical settings & may not be widely available as a regulated over-the-counter supplement. Information is provided for educational purposes only — not as a recommendation to use. See our Safety page.

Wellbutrin (Bupropion)

Wellbutrin is a dopamine-norepinephrine reuptake inhibitor approved for treating depression & aiding smoking cessation. It is also used off-label for ADHD & weight management.

mental-healthdepressionfocusweight-management
Evidence last reviewed: 05 Apr 2026
Buy this ingredient← Back
Supplement note
Private note on this supplement

Save how you reacted, what dose worked, what to watch for, or anything you want to remember later in your Notes tab.

Sign in to keep a private note on Wellbutrin (Bupropion).
Sign in
Biomarkers studied
Outcomes directly measured across the evidence records below
Metabolic
Body Weight
Cognitive
Focus / AttentionMood / Wellbeing
Evidence
4 records
ADHD symptom management
Adults with ADHD • Systematic review
PUBMEDLow

Bupropion showed improvement in clinical response for ADHD symptoms compared to placebo.

Dose: 300 mg
Citation: Ofori et al. (2023). Cytisine for smoking cessation: A systematic review and meta-analysis.
The study includes bupropion as part of ADHD pharmacotherapy.
Smoking cessation
Smokers with and without psychiatric disorders • RCT
PUBMEDHigh

Bupropion, when combined with behavioral counseling, significantly increased quit rates compared to usual care.

Dose: 300 mgDuration: 6 months
Citation: Anthenelli et al. (2016). Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial.
Weight management
Adults with obesity • Systematic review
PUBMEDModerate

Naltrexone-bupropion was effective in regulating appetite & contributing to weight loss.

Dose: 300 mgForm: Naltrexone-Bupropion
Citation: Rigotti et al. (2022). Treatment of Tobacco Smoking: A Review.
The study discusses the use of naltrexone-bupropion for weight management.
Major depressive disorder
Patients with major depressive disorder • RCT
PUBMEDModerate

AXS-05 (dextromethorphan-bupropion) showed significant improvement in depression symptoms compared to placebo.

Dose: 300 mgDuration: 6 weeksForm: Dextromethorphan-Bupropion
Citation: Tabuteau et al. (2022). Effect of AXS-05 (Dextromethorphan-Bupropion) in Major Depressive Disorder: A Randomized Double-Blind Controlled Trial.
Forms
Tablet
Commonly prescribed form for oral administration.
Extended-release tablet
Allows for once-daily dosing.

Stacks containing Wellbutrin (Bupropion)

Public community stacks that include this ingredient.

Explore all stacks →
No public stacks include this ingredient yet.