StackTerminal.Health

Vitamin K2 (MK-7)

Menaquinone-7 (MK-7) is the long-chain form of vitamin K2 that activates matrix Gla-protein and osteocalcin, directing calcium to bone rather than arterial walls; evidence from RCTs demonstrates preservation of bone mineral density and reduction of vertebral height loss in postmenopausal women.

bonecardiovascularlongevitycalcium-metabolismhormonal
Dosing model
FLATFixed dose (no body-weight scaling).
Min dose
0 mg
Max dose
0 mg
Rounding
0 mg
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Evidence
2 records
Bone mineral density and vertebral fracture prevention
Healthy postmenopausal women • RCT
Moderate

A 3-year double-blind RCT (n=244) of MK-7 180 mcg/day found significantly attenuated age-related decline in bone mineral content and BMD at lumbar spine and femoral neck versus placebo, plus reduced vertebral height loss in the lower thoracic region; bone strength indices were also favorably affected.

Dose: 0 mg • Duration: 3 years
Citation: Knapen MHJ, Drummen NE, Smit E, Vermeer C, Theuwissen E. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int. 2013;24(9):2499-507.
Dose expressed in mg (180 mcg = 0.18 mg). MK-7 has a ~72-hour half-life enabling once-daily dosing.
Fracture incidence and bone density in postmenopausal osteoporosis
Postmenopausal women with or at risk for osteoporosis • systematic review and meta-analysis of RCTs
Moderate

Meta-analysis of 16 RCTs (n=6,425) found vitamin K2 supplementation significantly improved lumbar spine BMD and reduced fracture incidence after exclusion of one outlier study; undercarboxylated osteocalcin was consistently reduced, indicating enhanced bone mineralization.

Dose: 0 mg • Duration: 6 months – 3 years
Citation: Ma ML, Ma ZJ, He YL, et al. Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials. Front Public Health. 2022;10:979649.
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