Vitamin B6 (Pyridoxine)
Essential coenzyme involved in neurotransmitter synthesis, amino acid metabolism, & immune function.
Evidence last reviewed: 04 Apr 2026
Vitamin B6 is an essential nutrient that supports neurotransmitter synthesis and immune function. However, high doses can lead to nerve damage, so moderation is key.
Peripheral neuropathy (tingling/numbness in hands and feet) with sustained high doses
Context: doses >100mg/day for months
Pyridoxine HCl form associated with higher neuropathy risk — P5P (active) form better tolerated at therapeutic doses
Summarized study outcomes with population, design, grade, and effect data.
Research shows moderate evidence for Vitamin B6's effectiveness in improving PMS mood symptoms and providing a modest antidepressant effect when combined with magnesium. However, more studies are needed to fully understand its benefits and optimal dosing.
PMS symptoms / moodWomen with PMS; adults with depression · RCTsModerate
Consistent improvement in PMS mood symptoms; modest antidepressant signal when combined with magnesium.
Stacks containing Vitamin B6 (Pyridoxine)
Public community stacks that include this ingredient.