Vitamin B6 (Pyridoxine)
Essential coenzyme involved in neurotransmitter synthesis, amino acid metabolism, & immune function.
dailybrainhormoneswomens-health
Evidence last reviewed: 04 Apr 2026
Trade-offs & context
Known concerns, timing considerations, & interactions
Neural
Peripheral neuropathy (tingling/numbness in hands and feet) with sustained high doses
Context: doses >100mg/day for months
Tolerance
Pyridoxine HCl form associated with higher neuropathy risk — P5P (active) form better tolerated at therapeutic doses
Dot colour: ●High concern ●Moderate ● Low / note
Biomarkers studied
Outcomes directly measured across the evidence records below
Cognitive
Mood / Wellbeing
Evidence
1 record
PMS symptoms / mood
Women with PMS; adults with depression • RCTs
PUBMEDModerate
Consistent improvement in PMS mood symptoms; modest antidepressant signal when combined with magnesium.
Dose: 50 mgDuration: 2–3 menstrual cycles
High doses (>200 mg/day long-term) can cause peripheral neuropathy.
Forms
Pyridoxine HCl
Standard form.
Pyridoxal-5-phosphate (P5P)
Active coenzyme form.
Stacks containing Vitamin B6 (Pyridoxine)
Public community stacks that include this ingredient.
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