Vitamin B12
Essential cobalamin; deficiency common in vegans, older adults, & those on metformin. Supplementation corrects deficiency reliably.
dailyenergybrainvegans
Evidence last reviewed: 04 Apr 2026
Trade-offs & context
Known concerns, timing considerations, & interactions
Note
Cyanocobalamin releases trace cyanide on metabolism — methylcobalamin preferred for those with MTHFR variants or very high-dose supplementation
Dot colour: ●High concern ●Moderate ● Low / note
Evidence
1 record
B12 status / neurological function
Deficient adults; vegans; older adults • RCTs + observational
PUBMEDHigh
Reliably corrects deficiency; improves energy & neurological symptoms in deficient individuals.
Dose: 1 mgDuration: 8–12 weeks
No established benefit in non-deficient adults; high oral doses (1000 mcg) compensate for poor absorption.
Forms
Methylcobalamin
Active form; preferred by some.
Cyanocobalamin
Most studied; highly stable.
Hydroxocobalamin
Long-acting injection form.
Stacks containing Vitamin B12
Public community stacks that include this ingredient.
No public stacks include this ingredient yet.