StackTerminal.Health

BETA
Research compound

This compound is primarily studied in research/clinical settings & may not be widely available as a regulated over-the-counter supplement. Information is provided for educational purposes only — not as a recommendation to use. See our Safety page.

Trazodone

Trazodone is a serotonin antagonist & reuptake inhibitor (SARI) primarily prescribed for depression & widely used off-label for insomnia, with evidence supporting improvements in sleep architecture & depressive symptoms.

sleepmental-healthdepressionanxiety
Evidence last reviewed: 05 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Sleep
Sleep Quality (subjective)
Cognitive
Mood / Wellbeing
Evidence
4 records
Depression symptom reduction
Adults with major depressive disorderSystematic review
PUBMEDModerate

Trazodone was found to be more effective than placebo in reducing symptoms of major depressive disorder.

Dose: 100 mg
Sleep quality improvement
Adults with insomniaSystematic review
PUBMEDModerate

Trazodone was effective in improving sleep quality compared to placebo.

Dose: 100 mg
Insomnia treatment efficacy
Adults with insomniaSystematic review
PUBMEDModerate

Trazodone was found to be effective in the acute treatment of insomnia, though associated with poor tolerability.

Dose: 100 mg
Nightmare reduction in PTSD
Adults with PTSDSystematic review
PUBMEDLow

Trazodone was used in the pharmacological management of nightmares associated with PTSD.

Dose: 100 mg
Forms
Tablet
Commonly prescribed form for oral administration.
Extended-release tablet
Designed for once-daily dosing to maintain stable blood levels.

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