StackTerminal.Health

BETA
Research compound

This compound is primarily studied in research/clinical settings & may not be widely available as a regulated over-the-counter supplement. Information is provided for educational purposes only — not as a recommendation to use. See our Safety page.

Thymosin Beta-4 (TB4) / TB-500 (fragment)

TB4 has animal wound-healing data & has been evaluated in human wound indications (e.g., venous stasis ulcers). TB-500 is a synthetic fragment; direct clinical evidence for TB-500 itself is limited.

research-chemicalpeptidewound-healingangiogenesis
Evidence last reviewed: 04 Apr 2026
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Evidence
3 records
Wound healing acceleration (preclinical)
Rat full-thickness wound modelControlled animal study
PUBMEDLow

In a rat wound model, TB4 increased re-epithelialization & improved contraction versus saline controls, supporting a wound-healing mechanism in animals.

Dose: Duration: Days (animal wound follow-up)
Wound healing (clinical development)
Patients with venous stasis ulcersRegistered phase 2 trial (TB4 gel)
ClinicalTrialsLow

TB4 gel has been studied in venous stasis ulcer indications; registry evidence supports clinical testing, though effect sizes depend on the specific trial & endpoint reporting.

Dose: Duration: Up to 84 days (per registry)Form: TB4 gel
Wound healing (reviewed clinical context)
Stasis and pressure ulcer clinical programsReview article
PUBMEDLow

A review summarizes phase 2 wound-healing programs reporting faster healing in those that did heal; note that these are not sports injury RCTs.

Dose:
Forms
Peptide (TB4)
Naturally occurring peptide studied in animals and humans.
Peptide fragment (TB-500)
Fragment derived from TB4 active region; less direct clinical documentation.

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