StackTerminal.Health

BETA

Thiamine (Vitamin B1)

Thiamine is an essential B vitamin crucial for glucose metabolism and mitochondrial function, particularly important for individuals with heavy alcohol use or those undergoing bariatric surgery. It supports cardiac and neurological function.

energyneurologicalneuroprotectionnutritional
Evidence last reviewed: 20 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Cognitive
Cognitive FunctionNeuroprotection / NGF
Evidence
4 records
Cognitive function
Patients with dementiaSystematic review
PUBMEDModerate

Thiamine supplementation showed a positive impact on cognitive performance, especially when combined with folic acid.

Dose: 100 mg
Neurological symptoms in Wernicke's encephalopathy
Patients with Wernicke's encephalopathySystematic review
PUBMEDModerate

IV thiamine alleviated neurological symptoms and cognitive dysfunction associated with Wernicke's encephalopathy.

Dose: 500 mgForm: Intravenous
Thiamine deficiency prevalence
Post-bariatric surgery patientsMeta-analysis
PUBMEDHigh

27% of patients undergoing bariatric surgery experience vitamin B1 deficiency, indicating the need for lifelong supplementation.

Dose: 100 mg
Neurological and clinical findings in Wernicke's encephalopathy
Patients with Wernicke's encephalopathyCase series
PUBMEDLow

IV thiamine led to partial or complete resolution of symptoms in 90% of cases.

Dose: 500 mgForm: Intravenous
Forms
Oral
Commonly used for general supplementation.
Intravenous
Used in clinical settings for acute deficiencies or conditions like Wernicke's encephalopathy.

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