Theacrine

Purine alkaloid structurally related to caffeine; found in Camellia kucha tea; marketed for energy & focus with less tolerance development than caffeine.

focusalertnessenergy

Evidence last reviewed: 04 Apr 2026

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Biomarkers studied

Outcomes directly measured across the evidence records below

Cognitive

Focus / AttentionReaction TimeCognitive Function

Evidence

2 records

Subjective energy, alertness, & focus

Healthy young adults (n=20) • RCT (double-blind, crossover)

PUBMEDLow

Trends for higher self-reported attentiveness, alertness, focus, & energy with theacrine-containing supplement vs. caffeine & placebo; no significant differences on objective cognitive tests (trail making, digit symbol, reaction time).

Dose: 300 mgDuration: Acute (single dose)

Citation: Kuhman DJ et al. Nutrients. 2015;7(11):9618–9632.

Small sample (n=20); self-reported outcomes more positive than objective measures. Tolerance-resistance claim lacks human RCT confirmation.

Cognitive performance & reaction time (combined with caffeine)

Male e-gamers (n=50) • RCT (randomized crossover)

PUBMEDLow

Caffeine (125 mg) + TeaCrine (50 mg) + Dynamine (75 mg) combination improved Flanker inhibitory control & Psychomotor Vigilance Task reaction time vs. placebo; theacrine's isolated contribution is unclear.

Dose: 50 mgDuration: Acute

Citation: Cintineo HP et al. Front Psychol. 2022;13:849804.

Most human evidence uses combination formulas; isolated theacrine RCTs remain limited.

Forms

TeaCrine® (standardized theacrine)

Patented form; used in most human studies.

Stacks containing Theacrine

Public community stacks that include this ingredient.

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focus

Clean Stimulant Focus Stack

by@athlete

Supports alertness with lower jitter risk than caffeine.

Theacrine

100mg

L-Theanine

200mg

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