StackTerminal.Health

BETA

Sulbutiamine

Sulbutiamine is a synthetic derivative of thiamine that crosses the blood-brain barrier more effectively, potentially improving memory and reducing fatigue, particularly in conditions like multiple sclerosis and post-infectious asthenia.

energynootropiccognitivememorymood
Evidence last reviewed: 20 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Cognitive
Mood / WellbeingCognitive Function
Evidence
3 records
Psycho-behavioral inhibition reduction
Patients with major depressive episodesRCT
PUBMEDModerate

Sulbutiamine was found to reduce psycho-behavioral inhibition in patients with major depressive episodes when used alongside clomipramine.

Dose: 600 mgDuration: 8 weeksForm: Arcalion
Study involved combination therapy with clomipramine.
Fatigue reduction
Patients with chronic postinfectious fatigueRCT
PUBMEDModerate

Patients treated with sulbutiamine reported significantly less incapacitation in social, professional, and family life compared to placebo.

Dose: 400 mgDuration: 4 weeks
Cognitive performance
General populationRCT
PUBMEDLow

Sulbutiamine may improve cognitive performance and reduce fatigue, although evidence is preliminary.

Dose: 400 mgDuration: 4 weeksForm: Arcalion
Study focused on psycho-behavioral inhibition.
Forms
Tablet
Commonly available in 200 mg tablets.
Capsule
Available in various dosages, often combined with other nootropics.

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