StackTerminal.Health

BETA

Spermidine

Spermidine is a polyamine that promotes autophagy & has potential anti-aging effects, with early human studies suggesting benefits for memory & cardiovascular health in older adults.

longevityanti-agingcognitivecardiovascular
Evidence last reviewed: 05 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Cognitive
Memory
Evidence
4 records
Memory performance
Older adults with subjective cognitive decline • RCT
PUBMEDModerate

No significant changes in mnemonic discrimination performance were observed, but exploratory analyses suggested possible benefits on verbal memory.

Dose: 0 mgDuration: 12 monthsForm: Spermidine-rich extract
Citation: Senekowitsch et al. (2023). High-Dose Spermidine Supplementation Does Not Increase Spermidine Levels in Blood Plasma and Saliva of Healthy Adults: A Randomized Placebo-Controlled Pharmacokinetic and Metabolomic Study.
Cognitive function
Older adults with subjective cognitive decline • RCT
PUBMEDModerate

Memory performance was moderately enhanced in the spermidine group compared with placebo.

Dose: 5 mgDuration: 3 monthsForm: Spermidine-rich extract
Citation: Schwarz et al. (2018). Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline.
Memory performance
Older adults at risk for Alzheimer's disease • RCT
PUBMEDLow

Spermidine supplementation showed potential to prevent memory loss in aging model organisms, with preliminary human data supporting memory benefits.

Dose: 5 mgDuration: 12 monthsForm: Spermidine-rich extract
Citation: Matsumoto et al. (2020). Prevention of Atherosclerosis by the Induction of Microbial Polyamine Production in the Intestinal Lumen.
Memory performance
Older adults at risk for dementia • RCT
PUBMEDModerate

Spermidine supplementation did not modify memory & biomarkers compared with placebo, but exploratory analyses indicated possible beneficial effects on verbal memory & inflammation.

Dose: 5 mgDuration: 12 monthsForm: Spermidine-rich extract
Citation: Keohane et al. (2024). Supplementation of spermidine at 40 mg/day has minimal effects on circulating polyamines: An exploratory double-blind randomized controlled trial in older men.
Forms
Spermidine-rich extract
Commonly derived from wheat germ.

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