StackTerminal.Health

BETA

Spermidine

Spermidine is a polyamine that promotes autophagy & has potential anti-aging effects, with early human studies suggesting benefits for memory & cardiovascular health in older adults.

longevityanti-agingcognitivecardiovascular

Evidence last reviewed: 05 Apr 2026

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Bottom line

Spermidine is a polyamine that may support memory and cardiovascular health in older adults. While early studies show promise, more robust evidence is needed to confirm its benefits.

Summarized study outcomes with population, design, grade, and effect data.

4 recordsBest grade:Moderate
Cognitive functionMemory performance

The evidence for spermidine's effects on memory and cognitive function is mixed, with some studies showing moderate enhancements while others report no significant changes. The overall strength of the evidence is low to moderate, indicating a need for further research to clarify its benefits.

Biomarkers studied
Cognitive
Memory
Cognitive function
Older adults with subjective cognitive decline · RCT
Moderate

Memory performance was moderately enhanced in the spermidine group compared with placebo.

Dose: 5 mgDuration: 3 monthsForm: Spermidine-rich extract
Citation: Schwarz et al. (2018). Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline.
Memory performance
Older adults at risk for Alzheimer's disease · RCT
Low

Spermidine supplementation showed potential to prevent memory loss in aging model organisms, with preliminary human data supporting memory benefits.

Dose: 5 mgDuration: 12 monthsForm: Spermidine-rich extract
Citation: Matsumoto et al. (2020). Prevention of Atherosclerosis by the Induction of Microbial Polyamine Production in the Intestinal Lumen.
Memory performance
Older adults with subjective cognitive decline · RCT
Moderate

No significant changes in mnemonic discrimination performance were observed, but exploratory analyses suggested possible benefits on verbal memory.

Dose: 0 mgDuration: 12 monthsForm: Spermidine-rich extract
Citation: Senekowitsch et al. (2023). High-Dose Spermidine Supplementation Does Not Increase Spermidine Levels in Blood Plasma and Saliva of Healthy Adults: A Randomized Placebo-Controlled Pharmacokinetic and Metabolomic Study.
Memory performance
Older adults at risk for dementia · RCT
Moderate

Spermidine supplementation did not modify memory & biomarkers compared with placebo, but exploratory analyses indicated possible beneficial effects on verbal memory & inflammation.

Dose: 5 mgDuration: 12 monthsForm: Spermidine-rich extract
Citation: Keohane et al. (2024). Supplementation of spermidine at 40 mg/day has minimal effects on circulating polyamines: An exploratory double-blind randomized controlled trial in older men.

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