Soy Isoflavones

May reduce menopausal hot flash frequency/severity with small average effect; evidence is mixed and response varies.

womens-healthmenopauselongevitymetabolic-health

Dosing model

FLATFixed dose (no body-weight scaling).

Min dose

40 mg

Max dose

80 mg

Rounding

10 mg

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Evidence

2 records

Hot flash frequency/severity

Peri-/postmenopausal women • Evidence synthesis / clinical summary

Low

Soy isoflavone supplements or soy protein may reduce hot flashes, but average effect is small and results are not fully consistent.

Dose: 50 mg • Duration: 6–12 weeks (typical study windows)

Citation: NCCIH – Menopausal Symptoms and Complementary Health Approaches (Soy)

Hot flash frequency reduction — quantitative meta-analysis

Peri-/postmenopausal women • Meta-analysis of RCTs

Moderate

Model-based meta-analysis of 16 RCTs (~1,710 subjects) found soy isoflavones reduced hot flash frequency by a maximal 25.2% over placebo — a statistically real but modest effect compared to estradiol, with slow onset over several weeks.

Dose: 54 mg • Duration: Varies (pooled across trials)

Citation: Li L, et al. Quantitative efficacy of soy isoflavones on menopausal hot flashes. Br J Clin Pharmacol. 2015;79(4):593-604.

Forms

Capsule

Also achievable via soy foods