StackTerminal.Health

BETA

Sodium Hyaluronate

Sodium Hyaluronate is a form of hyaluronic acid that is used primarily for its joint lubrication and skin hydration properties. It works by retaining moisture and providing cushioning in the joints and skin, leading to improved joint function and skin elasticity.

joint-healthskinhydrationelasticityanti-aginglubricationmoisture-retentioncollageninflammationantioxidant
Evidence last reviewed: 29 Apr 2026
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Trade-offs & context
Known concerns, timing considerations, & interactions
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Cost

Context: Higher doses may increase the cost of supplementation.

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Absorption

Context: Oral forms may have variable absorption rates.

Dot colour: High concern  Moderate   Low / note
Biomarkers studied
Outcomes directly measured across the evidence records below
Inflammation
CRP (Inflammation)IL-6
Evidence
4 records
Joint Health
Adults with osteoarthritisRandomized Controlled Trial
PUBMEDModerate

Improved joint function and reduced pain.

Dose: 150 mgDuration: 12 weeksForm: Oral CapsuleTiming: Daily
Significant improvement in knee osteoarthritis symptoms.
Skin Hydration
Adults with dry skinClinical Trial
PUBMEDHigh

Increased skin hydration and elasticity.

Dose: 75 mgDuration: 8 weeksForm: Topical GelTiming: Twice daily
Topical application showed significant improvement in skin moisture.
Anti-Aging Effects
Middle-aged adultsObservational Study
PUBMEDLow

Reduction in fine lines and wrinkles.

Dose: Duration: 6 monthsForm: Topical GelTiming: Daily
Long-term use associated with visible reduction in aging signs.
Inflammation Reduction
Adults with inflammatory conditionsMeta-Analysis
PUBMEDModerate

Moderate reduction in inflammatory markers.

Dose: 150 mgDuration: VariedForm: Oral CapsuleTiming: Daily
Effective in reducing CRP and IL-6 levels.
Forms

Stacks containing Sodium Hyaluronate

Public community stacks that include this ingredient.

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longevityanti-agingcellular-health

Bryan Johnson's Blueprint Longevity Mix is the core daily powder from his self-quantified anti-aging protocol. It combines NAD+ pathway support (CaAKG), collagen precursors (Glycine, Lysine, Vitamin C), joint protection (Glucosamine, Sodium Hyaluronate), mitochondrial support (Creatine, CoQ10-adjacent), and antioxidant defence (Glutathione, Taurine). Every ingredient is dosed at clinically relevant levels validated through continuous biomarker tracking.

Creatine Monohydrate
2500mg
Calcium Alpha-Ketoglutarate (CaAKG)
2000mg
Taurine
1500mg
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