StackTerminal.Health

BETA

Saffron (Crocus sativus)

Saffron is a spice-derived supplement known for its antidepressant properties, showing comparable efficacy to SSRIs for mild-to-moderate depression with fewer side effects. It is also studied for its effects on PMS, memory, and appetite.

depressionmoodanxietyappetitememory
Evidence last reviewed: 20 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Cognitive
Mood / WellbeingFocus / AttentionNeuroprotection / NGFAnxiety
Evidence
4 records
Depression symptoms
Adults with mild to moderate depressionMeta-analysis
PUBMEDHigh

Saffron was found to be as effective as SSRIs in reducing depressive symptoms with fewer adverse events.

Dose: 30 mgDuration: 6-8 weeksForm: Extract
ADHD symptoms
Children and adolescents with ADHDSystematic review
PUBMEDLow

Saffron demonstrated promise in improving ADHD symptoms with an acceptable safety profile.

Dose: 30 mgForm: Extract
Neuroprotection
General populationSystematic review
PUBMEDVery low

Saffron has potential neuroprotective effects, though more research is needed to confirm these findings.

Dose: 30 mgForm: Extract
Anxiety symptoms
Adults with anxietyMeta-analysis
PUBMEDModerate

Saffron showed a nonsignificant difference compared to SSRIs in reducing anxiety symptoms but had fewer adverse events.

Dose: 30 mgDuration: 6-8 weeksForm: Extract
Forms
Extract
Standardized extracts are commonly used in studies.
Capsule
Convenient form for consistent dosing.
Powder
Can be mixed with food or beverages.

Stacks containing Saffron (Crocus sativus)

Public community stacks that include this ingredient.

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moodanxietystress

Combining Kanna and Saffron can provide mood enhancement and anxiety reduction. Kanna is known for its anxiolytic and mood-enhancing properties, while Saffron has been shown to improve mood and reduce symptoms of anxiety.

Kanna (Sceletium tortuosum)
25mg
Saffron (Crocus sativus)
30mg
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