Rutin (Quercetin-3-rutinoside)
Rutin is a flavonoid glycoside of quercetin with anti-thrombotic, anti-inflammatory, and vascular-protective properties, commonly used for venous insufficiency and edema reduction.
cardiovascularanti-thromboticanti-inflammatoryantioxidant
Evidence last reviewed: 20 Apr 2026
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Evidence
3 records
Venous insufficiency symptoms
Patients with chronic venous insufficiency • Systematic review
PUBMEDModerate
Phlebotonics, including rutosides, probably reduce edema slightly compared to placebo.
Dose: 500 mg
Moderate-certainty evidence suggests slight reduction in edema.
Post-thrombotic syndrome prevention
Patients with chronic venous insufficiency • Systematic review
PUBMEDModerate
Venoactive compounds are recommended for prevention and treatment of post-thrombotic syndrome.
Dose: 500 mg
Evidence supports use in post-thrombotic syndrome.
Edema reduction
Patients with chronic venous insufficiency • RCT
PUBMEDModerate
Moderate-certainty evidence suggests phlebotonics reduce edema slightly compared to placebo.
Dose: 500 mg
Study focused on edema prevention during flights.
Forms
Capsule
Commonly available in 500 mg doses.
Tablet
Often used for standardized dosing.
Powder
Can be mixed with liquids for easier consumption.
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