Riboflavin (Vitamin B2)
Riboflavin is an essential B vitamin that functions as a cofactor in mitochondrial energy production and fatty acid oxidation. It is particularly effective in high doses for migraine prevention and may benefit individuals with mitochondrial disorders.
energyneurologicalmitochondrialnutritional
Evidence last reviewed: 20 Apr 2026
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Evidence
3 records
Migraine frequency reduction
Adults with migraines • Systematic review
PUBMEDHigh
Riboflavin supplementation significantly decreased migraine days, duration, frequency, and pain score.
Dose: 400 mgDuration: 3 months
Migraine prevention
Pediatric patients with migraines • Network Meta-Analysis
PUBMEDModerate
Vitamin B2 supplementation showed a positive impact on reducing the frequency and severity of migraine attacks.
Dose: 400 mg
Migraine attack reduction
Adults with chronic migraines • Systematic review and meta-analysis
PUBMEDHigh
Riboflavin significantly decreased the frequency and severity of migraine attacks.
Dose: 400 mg
Forms
Capsule
Commonly used for migraine prophylaxis.
Tablet
Standard form for dietary supplementation.
Powder
Can be mixed with liquids for easier consumption.
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