StackTerminal.Health

BETA
Research compound

This compound is primarily studied in research/clinical settings & may not be widely available as a regulated over-the-counter supplement. Information is provided for educational purposes only — not as a recommendation to use. See our Safety page.

Rapamycin

Rapamycin is an mTOR inhibitor primarily used as an immunosuppressant, with emerging evidence suggesting potential benefits in extending lifespan & improving aging biomarkers in humans.

longevityanti-agingimmunemetabolic
Evidence last reviewed: 05 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Cardiovascular
Blood Pressure
Immune
Immune Function
Evidence
4 records
Aging-related physiological improvements
Adults with aging-related diseasesSystematic review
PUBMEDModerate

Rapamycin & its derivatives improved physiological parameters associated with aging in the immune, cardiovascular, & integumentary systems.

Dose: 5 mg
Vascular anomaly treatment
Children with lymphatic malformationsSystematic review
PUBMEDModerate

Sirolimus was highly effective in treating vascular tumors & lymphatic malformations, with significant clinical improvement.

Dose: 5 mgForm: Oral
Healthspan metrics
AdultsRCT
PUBMEDModerate

Rapamycin influenced safety & healthspan metrics positively after one year.

Dose: 5 mgDuration: 1 year
Skin aging markers
Adults with skin agingRandomized trial
PUBMEDLow

Topical rapamycin reduced markers of senescence & aging in human skin.

Dose: 5 mgForm: Topical
Forms
Oral
Commonly used for systemic effects.
Topical
Used for localized effects, particularly in skin aging.

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