StackTerminal.Health

BETA
Research compound

This compound is primarily studied in research/clinical settings & may not be widely available as a regulated over-the-counter supplement. Information is provided for educational purposes only — not as a recommendation to use. See our Safety page.

Psilocybin

Psilocybin is a classic psychedelic that acts as a serotonin 2A receptor agonist, showing promise in clinical trials for treating depression, PTSD, addiction, & existential distress in terminal illness.

mental-healthdepressionanxietyneuroplasticity
Evidence last reviewed: 05 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Cognitive
Mood / WellbeingAnxiety
Evidence
5 records
Depression severity
Patients with major depressive disorderSystematic review
PUBMEDHigh

Psilocybin significantly reduced depression severity compared to control.

Dose: 25 mg
Depression severity
Patients with major depressive disorderRCT
PUBMEDModerate

Psilocybin was associated with a significant reduction in depression scores compared to niacin placebo.

Dose: 25 mgDuration: 6 weeksForm: Synthetic PsilocybinTiming: Single dose
Depression severity
Patients with major depressive disorderRCT
PUBMEDModerate

Psilocybin showed greater reduction in depression scores compared to escitalopram.

Dose: 25 mgDuration: 6 weeksForm: Synthetic PsilocybinTiming: Two doses 3 weeks apart
Compared to escitalopram, a standard antidepressant.
Depression severity
Patients with major depressive disorderRCT
PUBMEDModerate

Psilocybin showed a greater reduction in depression scores compared to escitalopram.

Dose: 25 mgDuration: 6 weeksForm: Synthetic PsilocybinTiming: Two doses 3 weeks apart
Compared to escitalopram, a standard antidepressant.
Depression & anxiety
Patients with life-threatening cancerRCT
PUBMEDModerate

Psilocybin produced substantial & sustained decreases in depression & anxiety.

Dose: 25 mg
Forms
Synthetic Psilocybin
Used in clinical trials for precise dosing.
Psilocybin Mushrooms
Natural source, variable psilocybin content.

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