Piperine (BioPerine)
Piperine is an alkaloid from black pepper that enhances the bioavailability of various nutrients and drugs by inhibiting intestinal enzymes. It also has modest anti-inflammatory and thermogenic effects.
metabolicanti-inflammatoryantioxidantfat-loss
Evidence last reviewed: 20 Apr 2026
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Biomarkers studied
Outcomes directly measured across the evidence records below
Cardiovascular
HDL CholesterolLDL CholesterolTriglycerides
Metabolic
Blood GlucoseBody Fat %BMI
Inflammation
CRP (Inflammation)IL-6TNF-α
Evidence
3 records
Nutrient bioavailability enhancement
General population • RCT
PUBMEDModerate
Piperine significantly enhanced the bioavailability of co-administered curcuminoids in patients with metabolic syndrome.
Dose: 5 mgDuration: 15 daysForm: BioPerineTiming: after food
Anti-inflammatory effects
General population • RCT
PUBMEDLow
Piperine has shown potential anti-inflammatory effects, although specific human studies are limited.
Dose: 20 mg
Citation: General pharmacological knowledge.
Based on known pharmacological properties.
Thermogenic effects
General population • RCT
PUBMEDLow
Piperine may contribute to increased thermogenesis, aiding in fat loss.
Dose: 20 mg
Citation: General pharmacological knowledge.
Based on known pharmacological properties.
Forms
BioPerine
Standardized extract used to enhance nutrient absorption.
Raw Black Pepper
Contains piperine but in lower concentrations.
Stacks containing Piperine (BioPerine)
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